Closed-loop and safety-preserving control in anesthesia

Klaske Van Heusden, University of British Columbia, Vancouver, Canada

Abstract:  General anesthesia as routinely used in the operating room requires careful titration of a combination of drugs. In current practice, the anesthesiologist manually adjusts drug dosing, based on the observed patient response. Closed-loop technology has been shown to outperform manual anesthesia in terms of control performance. The main challenges for closed-loop anesthesia arise from the large variability between patients, while patient safety is critical. The goal of our research is to deliver a device that ensures patient safety and meets requirements for regulatory approval. Our system has been evaluated in over 200 clinical cases. I will present 1) an overview of our approach to the design of robust propofol (anesthetic) and remifentanil (opioid) controllers, and 2) recent theoretical results on safety-preserving control for uncertain systems, using falsification to reduce conservatism.

Biography:  Klaske van Heusden is a research associate at the University of British Columbia, Vancouver, Canada. She obtained a M.Sc. degree from the Delft University of Technology, The Netherlands (2004) and a Ph.D. degree from the Ecole Polytechnique Fédérale de Lausanne, Switzerland (2010), where she specialized in identification for control. She worked on modeling for the artificial pancreas during a post-doctoral fellowship at the University of California, Santa Barbara, USA. She currently leads the development of a closed-loop anesthesia device. Her research interest include identification for control, robust control, and data-driven methods with applications in biomedical engineering and mechatronics.